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Preoperative assessment of gastric cancer using multi-slice spiral ct perfusion imaging: A study of its diagnostic value
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F. Peng   , J. Song , Y. Zhang , Q. Peng |
| Large aperture CT room, Shandong Cancer Hospital, Jinan City, Shandong Province, 250117 China , jack6558@163.com |
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Abstract: (13 Views) |
Background: Globally, gastric cancer (GC) continues to be a primary driver of cancer deaths, as delayed diagnoses frequently lead to unfavorable clinical outcomes. Accurate preoperative assessment is critical for optimizing treatment strategies and enhancing patient outcomes. This research analyzed the preoperative evaluation value of multi-slice spiral computed tomography (MSCT) perfusion imaging in GC. Material and Methods: A cohort of 112 GC patients was recruited between January 2022 and April 2024 for quantification of MSCT perfusion metrics, including blood flow (BF), blood volume (BV), permeability surface (PS), and mean transit time (MTT). Results: Advanced-stage GC exhibited significantly higher BF, BV, and PS than early-stage disease (P<0.05). TNM stage progression (Ia+Ib → III+IIIa → III+IV) correlated with increasing BF, BV, and PS (P<0.05), while tumor location showed no significant parameter differences. Well-differentiated tumors had higher BF and PS but lower MTT than poorly differentiated cases (P<0.05). Patients without lymph node metastasis (LNM) or distant metastasis demonstrated reduced perfusion parameters, with BF and PS being statistically lower in non-metastatic groups (P<0.05). Conclusion: These findings suggest that MSCT perfusion imaging effectively reflects hemodynamic changes and provides valuable insights into tumor staging, differentiation, and metastasis, supporting its clinical utility in preoperative GC evaluation. |
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| Keywords: Stomach neoplasms, multidetector computed tomography, perfusion imaging, preoperative period, neoplasm staging, hemodynamics. |
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Full-Text [PDF 801 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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