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:: Volume 24, Issue 2 (4-2026) ::
Int J Radiat Res 2026, 24(2): 353-358 Back to browse issues page
Relationship between abnormal esophageal sphincter pressure and application of Nas jejunal-gastric nutrition tube in elderly patients after radiotherapy with gastroesophageal reflux
Y. Cao , J. Zhao , S. Wang , X. Zhou , X. Du , Y. Qin
Department of Neurology, Eighth People's Hospital of Hebei Province, Shijiazhuang, 050011, China , zhaojing820714@163.com
Abstract:   (672 Views)
Background: Gastroesophageal reflux (GER) is a common complication after radiotherapy, potentially influenced by changes in esophageal sphincter pressure and nutrition tube placement. To investigate the relationship between Nas jejunal-gastric (NG-J) tube application and abnormal esophageal sphincter pressure in elderly patients with GER after radiotherapy. Materials and Methods: A prospective observational study was conducted on elderly patients with confirmed GER who underwent external beam radiotherapy for thoracic or head-and-neck malignancies between 2022 and 2024. Radiotherapy was delivered using intensity-modulated radiotherapy (IMRT) with a total dose of 50-70 Gy in daily fractions of 1.8-2.0 Gy. Esophageal manometry was performed before and within 1 month after radiotherapy. Patients requiring NG-J tube feeding were compared to those without tube placement. Results: Among 86 patients, 38 received NG-J tube feeding and 48 did not. Post-radiotherapy, the NG-J tube group showed a significantly greater reduction in lower esophageal sphincter pressure (-12.4 ± 3.2 mmHg vs. -6.8 ± 2.9 mmHg, p<0.001) and a higher incidence of severe GER symptoms (63.2% vs. 33.3%, p=0.005). Radiation dose to the lower esophagus (>60 Gy) correlated with a greater decline in sphincter pressure (r = -0.58, p<0.001). Conclusion: NG-J tube application in elderly patients after high-dose radiotherapy is associated with more pronounced reductions in esophageal sphincter pressure and increased GER severity. Careful tube management and minimizing esophageal radiation exposure may reduce complications.
Keywords: Gastroesophageal reflux, esophageal sphincter, lower, manometry, radiotherapy, intensity-modulated, radiation dosage, enteral nutrition, Nasojejunal tube.
Full-Text [PDF 926 kb]   (208 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
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Cao Y, Zhao J, Wang S, Zhou X, Du X, Qin Y. Relationship between abnormal esophageal sphincter pressure and application of Nas jejunal-gastric nutrition tube in elderly patients after radiotherapy with gastroesophageal reflux. Int J Radiat Res 2026; 24 (2) :353-358
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Volume 24, Issue 2 (4-2026) Back to browse issues page
International Journal of Radiation Research
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