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Prognostic significance of ISG15 and CD3 in gastric cancer: Implications for immune regulation and radiosensitivity
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Y. Huang   , H.H. Liu , Y. Liang , X.Z. Xu , Z.H. Che , Y.Z. Lin , X.Q. Yu , X. Li , J.Y. Liang , T. Feng |
| Department of Nephrology, The People’s Hospital of Wuzhou, Wuzhou, 543001, Guangxi, China , ArthEynolds6017@hotmail.com |
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Abstract: (12 Views) |
Background: The ISG15 and CD3 play roles in immune regulation and cancer biology, but their prognostic and therapeutic significance in gastric cancer (GC) remains unclear. Materials and Methods: ISG15 expression was evaluated using TCGA and GTEx datasets across various cancers by enrichment and immune infiltration analyses. Immunohistochemistry was performed to assess ISG15 and CD3 expression and their associations with clinicopathological features, prognosis, and correlation with each other on 103 GC specimens. Results: ISG15 was overexpressed in multiple cancers, including GC, and correlated with immune cell infiltration. In the clinical cohort, ISG15 was highly expressed in 68.93% of cases, while CD3 was low in 89.32%. High ISG15 expression correlated with prolonged APTT, whereas high CD3 expression was associated with HER-2 mutation, elevated CA-125 and PCT, and reduced Hb and TC, all indicators of poor prognosis. Both ISG15 and CD3 expression correlated with shorter progression-free survival. A significant positive correlation between ISG15 and CD3 expression was observed. Conclusion: Elevated ISG15 and CD3 predict adverse clinicopathological features and prognosis in GC. Given their roles in immune regulation and DNA damage responses, ISG15 and CD3 may also serve as biomarkers of radiosensitivity, radiotherapy and combined radio-immunotherapy strategies. |
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| Keywords: Gastric cancer, ISG15 protein, CD3 antigens, radiosensitivity, tumour microenvironment, prognosis. |
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Full-Text [PDF 1171 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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