|
The orienting-exploratory activity of rats after oral intake of industrial dust of uranium ore
|
E.A. Saifulina   , P.K. Kazymbet , A.А. Musina , В. Aitbayeva , T. Kashkinbayev Ye , D.S. Tazhibayeva , K.A. Kusmambetova , S.A. Tulepbergenova , T.N. Tuleuov |
| Laboratory of Epidemiology and Medical Dosimetry Register of the Scientific Research Institute of Radiobiology and Radiation Protection, NpJSC “Astana Medical University”, Astana city, Kazakhstan , saifulina.e@amu.kz |
|
|
Abstract: (12 Views) |
Background: The functional abnormalities of the nervous system induced by the injection of industrial dust of uranium ore (DUO) into rat’s organism were studied. Materials and Methods: DUO was administered to nonlinear white male rats orally during a week in an amount of 5.8 g daily. The calculation of the individual absorbed and equivalent doses in the organs and tissues of rats allowed to include them to the range of small doses of ionizing radiation. To calculate the doses received by the animals during the experiment, the uranium content in biological samples was determined using an Agilent-7800 inductively coupled plasma mass spectrometer. The behavior of experimental animals was observed in the test in an open field condition for a month after incorporation into the body of long-lived radionuclides. Results: Analysis of behavioral acts in a group of males exposed to DUO at a dose of 50 maximum permissible concentration (MPC) indicated the predominance of passive-defensive forms of behavior, which was manifested by a decrease in motor and exploratory activity. The noted changes were evident throughout the study. At the same time, a slowdown in habituation processes was recorded, manifested in a small variability in the number of crossed squares and the number of vertical posts. Conclusion: The intake of DUO at a dose of 50 MPC changed the indices of locomotor and research activity of rats significantly along with an increased concentration of uranium in the organs and tissues of animals, including the brain. |
|
| Keywords: Indicative-research activity, ionizing radiation, nervous system, open field, uranium. |
|
|
Full-Text [PDF 799 kb]
(3 Downloads)
|
|
Type of Study: Original Research |
Subject:
Radiation Biology
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
