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:: Volume 10, Issue 3 And 4 (12-2012) ::
Int J Radiat Res 2012, 10(3 And 4): 183-186 Back to browse issues page
Megavoltage dose enhancement of gold nanoparticles for different geometric set-ups: Measurements and Monte Carlo simulation
S.H. Mousavie Anijdan , A. Shirazi , S.R. Mahdavi , A. Ezzati , B. Mofid , S. Khoei , M.A. Zarrinfard
, srmahdavi@hotmail.com
Abstract:   (11028 Views)
Background: Gold nanoparticles (GNPs) have been shown as a good radiosensitizer. In combination with radiotherapy, several studies with orthovoltage X-rays have shown considerable dose enhancement effects. This paper reports the dose enhancement factor (DEF) due to GNPs in 18 megavoltage (MV) beams. Materials and Methods: Different geometrical 50-nm GNPs configurations at a concentration of 5 mg/ml were used by both experimental and Monte Carlo (MC) simulation in a deep-seated tumor-like insertion within a phantom. Using MCNP repeated structure capability a large number of gold nanospheres with a semi-random distribution were applied to simulate this phantom based study. Thermoluminescence dosimetries were used to verify the process of irradiation and MC simulation. Results: Under geometries with different probable combinations of water and GNPs distribution in the tumor, the percentage depth dose and DEF were calculated. Incorporation of GNPs into the radiation field in our set-ups showed a 12% DEF. Conclusion: We show that the method of nanoparticles, distribution, and orientation can effectively change the DEF value. Iran. J. Radiat. Res., 2012 10(3‐4): 183‐186
Keywords: Monte Carlo simulation, gold nanoparticles (GNPs), dose enhancement.
Full-Text [PDF 236 kb]   (3772 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
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Mousavie Anijdan S, Shirazi A, Mahdavi S, Ezzati A, Mofid B, Khoei S et al . Megavoltage dose enhancement of gold nanoparticles for different geometric set-ups: Measurements and Monte Carlo simulation. Int J Radiat Res 2012; 10 (3 and 4) :183-186
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Volume 10, Issue 3 And 4 (12-2012) Back to browse issues page
International Journal of Radiation Research
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