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AWT IMAGE

AWT IMAGE

Volume 10, Issue 3 And 4 (12-2012)                   Int J Radiat Res 2012, 10(3 And 4): 183-186 | Back to browse issues page

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Mousavie Anijdan S, Shirazi A, Mahdavi S, Ezzati A, Mofid B, Khoei S et al . Megavoltage dose enhancement of gold nanoparticles for different geometric set-ups: Measurements and Monte Carlo simulation. Int J Radiat Res 2012; 10 (3 and 4) :183-186
URL: http://ijrr.com/article-1-987-en.html
, srmahdavi@hotmail.com
Abstract:   (11773 Views)
Background: Gold nanoparticles (GNPs) have been shown as a good radiosensitizer. In combination with radiotherapy, several studies with orthovoltage X-rays have shown considerable dose enhancement effects. This paper reports the dose enhancement factor (DEF) due to GNPs in 18 megavoltage (MV) beams. Materials and Methods: Different geometrical 50-nm GNPs configurations at a concentration of 5 mg/ml were used by both experimental and Monte Carlo (MC) simulation in a deep-seated tumor-like insertion within a phantom. Using MCNP repeated structure capability a large number of gold nanospheres with a semi-random distribution were applied to simulate this phantom based study. Thermoluminescence dosimetries were used to verify the process of irradiation and MC simulation. Results: Under geometries with different probable combinations of water and GNPs distribution in the tumor, the percentage depth dose and DEF were calculated. Incorporation of GNPs into the radiation field in our set-ups showed a 12% DEF. Conclusion: We show that the method of nanoparticles, distribution, and orientation can effectively change the DEF value. Iran. J. Radiat. Res., 2012 10(3‐4): 183‐186
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Type of Study: Original Research | Subject: Radiation Biology

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