[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 1, Issue 3 (12-2003) ::
Int J Radiat Res 2003, 1(3): 157-161 Back to browse issues page
[66Ga]Oxine complex preparation and stability as a possible PET radiopharmaceutical.
A. R. Jalilian, P. Rowshanfarzad, A. Rahiminejad, A.A. Rajamand, A. J. Novinrooz
Abstract:   (20461 Views)

Background: Gallium-66 (T1/2= 9.49 h) is an interesting radionuclide that has potential for positron emission tomography (PET) imaging of biological processes in intermediate to slow target tissue uptake. Oxine has been labeled with this radioisotope in the form of [66Ga]gallium chloride for its possible diagnostic properties.

Materials and methods: 66Ga was produced in the 30 MeV cyclotron (Cyclon-30, IBA) via the 66Zn(p,n)66Ga reaction.TLC was performed on polymer backed silica gel. A Gamma spectrometer HPGe detector was used for countings.

Results: After the bombardment, the production yield was 11.2 mCi/ m Ah. The [66Ga]Oxine complex was obtained at the pH=5 in phosphate buffer medium at 37 ° C in 10 minutes. Radio-TLC showed an overall radiochemical yield of 97% (radiochemical purity > 98%). The chemical stability of the complex was checked in vitro with a specific activity of 896 mCi/ml.

Conclusion: [66Ga]oxine can be used in diagnostic studies due to its suitable physico-chemical properties both in vitro and in vivo. Iran . J. Radiat. Res., 2003 1(3): 157 - 161

Keywords: oxine, positron emission tomography (PET), blood cell labeling, stability
Full-Text [PDF 124 kb]   (3505 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

A. R. Jalilian, P. Rowshanfarzad, A. Rahiminejad, A.A. Rajamand, A. J. Novinrooz. [66Ga]Oxine complex preparation and stability as a possible PET radiopharmaceutical.. Int J Radiat Res. 2003; 1 (3) :157-161
URL: http://ijrr.com/article-1-23-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 1, Issue 3 (12-2003) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 4419