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Efficacy of Hematoporphyrin mediated photo-sonodynamic therapy on mice breast cancer
S. Moshfegh, M. Jadidi, H. Hasanzadeh, R. Nasr, M. Mirmohammadkhani
Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran , Jadidim@semums.ac.ir
Abstract:   (124 Views)
Background: A combination of photodynamic and sonodynamic therapy (PSDT) may be a non-invasive method for cancer treatment, which incorporates a combination of low-intensity ultrasound, laser radiation, and a sensitizer agent. The goal of this research was to evaluate the effect of PSDT with Hematoporphyrin-encapsulated Mesoporous silica nanoparticles (HP-MSNs) as a sensitizer in the management of mice breast adenocarcinoma. Materials and Methods: One hundred and fifty-six female mice (tumor grafted) were separated into 26 groups; including sham, laser (650 nm), 4 groups of laser + HP or MSN-HP (2.5 and 5 mg/kg), 4 groups of laser + ultrasound (1and 3 MHz; 1, 2 W/cm2), 16 groups of PSDT + HP or HP-MSN. The tumor growth factors were used to assess the procedure findings. Results: The results indicate that PSDT with an injection of HP or HP-MSN is effective in delaying tumor growth (P<0.05). Overall comparison of data showed a non-significant difference between PSDT with HP-MSN groups. The time of T2 and T5 in the groups of PSDT with HP-MSN were increased in comparison with sham and that of PSDT with HP groups (P<0.05). The tumor growth inhibition ratio increased in all PSDT groups. This increase was transient and declined over 30 days of treatment. PSDT + HP-MSN had Grade I, while other groups had Grade III malignancy in the histological study. Conclusion: The research gave profound findings involving the employ of PSDT with HP-MSN as a photo/sonosensitizer for treating breast adenocarcinoma implanted in mice.
 
 
Keywords: Photodynamic therapy, sonodynamic therapy, laser, ultrasound, breast cancer.
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Type of Study: Original Research | Subject: Radiation Biology
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International Journal of Radiation Research
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