|
Analysis of application of uniportal video-assisted thoracoscopic surgery in the treatment of non-small cell lung cancer and value of improving the immune function of patients
|
T. Guo   , Y. Yu , H. Wang , B. Zhou , X. Zhang , D. Zhang , H. Li , Z. Sun |
| Department of Thoracic Surgery, Affiliated Hospital of Hebei University, No. 212, Yuhua East Road, Lianchi District, Baoding, Hebei,071000,China , surgerylihefei@sina.com |
|
|
Abstract: (605 Views) |
Background: To investigate the use of uniportal video-assisted thoracoscopic surgery (U-VATS) in the treatment of non-small cell lung cancer (NSCLC). Materials and Methods: A total of 82 patients with early NSCLC in our hospital from May 2019 to January 2021 were enrolled to this study. Forty-one patients treated with spontaneous breathing U-VATS were the research group (RG), and 41 with conventional thoracoscopy were the control group (CG). Fasting peripheral blood was drawn from patients before (T0), one (T1) and three days after surgery (T2), respectively. White blood cells (WBC), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), matrix metalloproteinase-9 (MMP-9) and T-lymphocyte subsets were measured in the blood. In addition, we counted the conversion rate to open chest and tracheal intubation in the RG, and compared the operation time, intraoperative bleeding, chest drainage, chest tube retention time, antibiotic application time, postoperative hospital stays and complications between groups. Finally, a 1-year prognostic follow-up was performed to record overall survival, chemotherapy rate, and recurrent metastasis rate. Results: At T1, WBC, IL-6, TNF-α, and MMP-9 were lower in the RG than in the CG, while immune function was better in the RG at T1 and T2 (P<0.05). Complication rates were lower in the RG than in the CG when compared (P>0.05). The prognosis of 1-year overall survival, chemotherapy rate, and recurrence rate were not different between the two groups (P>0.05). Conclusion: Spontaneous breathing U-VATS can effectively reduce the inflammation and enhance the stability of immune function in NSCLC patients undergoing surgery. |
|
| Keywords: Video-assisted thoracic surgeries, non-small cell lung cancer, immune system phenomena, inflammation, postoperative complications. |
|
|
Full-Text [PDF 766 kb]
(442 Downloads)
|
|
Type of Study: Original Research |
Subject:
Radiation Biology
|
|
|
|
|
|
|
| References |
1. Wu F, Wang L, Zhou C (2021) Lung cancer in China: current and prospect. Current Opinion in Oncology, 33(1): 40-46. [ DOI:10.1097/CCO.0000000000000703] [ PMID] 2. Alexander M, Kim SY, Cheng H (2020) Update 2020: Management of non-small cell lung cancer. Lung, 198(6): 897-907. [ DOI:10.1007/s00408-020-00407-5] [ PMID] [ ] 3. Herbst RS, Morgensztern D, Boshoff C (2018) The biology and management of non-small cell lung cancer. Nature, 553(7689): 446-454. [ DOI:10.1038/nature25183] [ PMID] 4. Jonna S and Subramaniam DS (2019) Molecular diagnostics and targeted therapies in non-small cell lung cancer (NSCLC): an update. Discovery Medicine, 27(148): 167-170. 5. Broderick SR (2020) Adjuvant and neoadjuvant immunotherapy in non-small cell lung cancer. Thoracic Surgery Clinics, 30(2): 215-220. [ DOI:10.1016/j.thorsurg.2020.01.001] [ PMID] 6. Elkhayat H and Gonzalez-Rivas D (2019) Non-intubated uniportal video-assisted thoracoscopic surgery. Journal of thoracic disease, 11(3): S220-S222. [ DOI:10.21037/jtd.2019.02.05] [ PMID] [ ] 7. Kim HK and Han KN (2017) Uniportal video-assisted thoracoscopic surgery segmentectomy. Thoracic Surgery Clinics, 27(4): 387-398. [ DOI:10.1016/j.thorsurg.2017.06.007] [ PMID] 8. Sanna S, Bertolaccini L, Brandolini J, et al. (2017) Uniportal video-assisted thoracoscopic surgery in hemothorax. Journal of Visualized Surgery, 3: 126. [ DOI:10.21037/jovs.2017.08.06] [ PMID] [ ] 9. Lerut T (2017) Uniportal video-assisted thoracoscopic surgery in esophageal diseases: an introduction. Journal of Visualized Surgery, 3: 182. [ DOI:10.21037/jovs.2017.11.04] [ PMID] [ ] 10. Huang PM and Lin WY (2020) Suction ventilation for uniportal video-assisted thoracic surgery without endotracheal intubation. The Annals of Thoracic Surgery, 109(4): e301-e303. [ DOI:10.1016/j.athoracsur.2019.10.040] [ PMID] 11. Bedetti B, Patrini D, Bertolaccini L, et al. (2018) Uniportal non-intubated thoracic surgery. Journal of Visualized Surgery, 4: 18. [ DOI:10.21037/jovs.2017.12.09] [ PMID] [ ] 12. Pennell NA, Arcila ME, Gandara DR, West H (2019) Biomarker testing for patients with advanced non-small cell lung cancer: Real-world issues and tough choices. American Society of Clinical Oncology educational book, American Society of Clinical Oncology, Annual Meeting, 39: 531-542, [ DOI:10.1200/EDBK_237863] [ PMID] 13. Ettinger DS, Wood DE, Aisner DL, Akerley W, et al. (2017) Non-small cell lung cancer version 5, 2017 NCCN clinical practice guidelines in oncology. Journal of the National Comprehensive Cancer Network: JNCCN, 15(4): 504-535. [ DOI:10.6004/jnccn.2017.0050] [ PMID] 14. Tandberg DJ, Tong BC, Ackerson BG, Kelsey CR (2018) Surgery versus stereotactic body radiation therapy for stage I non-small cell lung cancer: A comprehensive review. Cancer, 124(4): 667-678. [ DOI:10.1002/cncr.31196] [ PMID] 15. Aoki MN, Amarante MK, de Oliveira CEC, Watanabe MAE (2018) Biomarkers in non-small cell lung cancer: Perspectives of individualized targeted therapy. Anti-cancer Agents in Medicinal Chemistry, 18(15): 2070-2077. [ DOI:10.2174/1871520618666180827102101] [ PMID] 16. Scarci M, Gonzalez-Rivas D, Schmidt J, Bedetti B (2017) Management of intraoperative difficulties during uniportal video-assisted thoracoscopic surgery. Thoracic Surgery Clinics, 27(4): 339-346. [ DOI:10.1016/j.thorsurg.2017.06.002] [ PMID] 17. Hou X, Zhuang X, Zhang H, et al. (2017) Artificial pneumothorax: a safe and simple method to relieve pain during microwave ablation of subpleural lung malignancy. Minimally invasive therapy & allied technologies: MITAT: Official Journal of the Society for Minimally Invasive Therapy, 26(4): 220-226. [ DOI:10.1080/13645706.2017.1287089] [ PMID] 18. Hernandez-Arenas LA, Purmessur RD, Gonzalez-Rivas D (2018) Uniportal video-assisted thoracoscopic segmentectomy. Journal of Thoracic, (Suppl 10): S1205-S1214. [ DOI:10.21037/jtd.2018.02.47] [ PMID] [ ] 19. Sakaguchi M (2021) Kyobu geka. The Japanese Journal of Thoracic Surgery, 74(11): 921-924. 20. Galvez C, Navarro-Martinez J, Bolufer S, et al. (2017) Non-intubated uniportal left-lower lobe upper segmentectomy (S6). Journal of Visualized Surgery, 3: 48. [ DOI:10.21037/jovs.2017.03.12] [ PMID] [ ] 21. Cherchi R, Grimaldi G, Pinna-Susnik M, et al. (2020) Retrospective outcomes analysis of 99 consecutive uniportal awake lung biopsies: a real standard of care? Journal of Thoracic Disease, 12(9): 4717-4730. [ DOI:10.21037/jtd-20-1551] [ PMID] [ ] 22. Furák J and Szabó Z (2021) Spontaneous ventilation combined with double-lumen tube intubation in thoracic surgery. General Thoracic and Cardiovascular Surgery, 69(6): 976-982. [ DOI:10.1007/s11748-020-01572-3] [ PMID] 23. Wormser C and Runge JJ (2016) Advances in Laparoscopic Surgery. The Veterinary clinics of North America, Small Animal Practice, 46(1): 63-84. [ DOI:10.1016/j.cvsm.2015.08.001] [ PMID] 24. Cullinan DR, Schill MR, DeClue A, et al. (2017) Fundamentals of Laparoscopic Surgery: Not Only for Senior Residents. Journal of surgical education, 74(6): e51-e54. [ DOI:10.1016/j.jsurg.2017.07.017] [ PMID] [ ] 25. Mantovani S, Vannucci J, Bassi M, et al. (2021) Left uniportal VATS for lung decortication after chemical pleurodesis under spontaneous breathing in patient with lymphangiomyomatosis. Multimedia Manual of Cardiothoracic Surgery: MMCTS, 2021: 10, 1510/mmcts. [ DOI:10.21203/rs.3.rs-517829/v1] |
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
|
Guo T, Yu Y, Wang H, Zhou B, Zhang X, Zhang D, et al . Analysis of application of uniportal video-assisted thoracoscopic surgery in the treatment of non-small cell lung cancer and value of improving the immune function of patients. Int J Radiat Res 2023; 21 (4) :821-826 URL: http://ijrr.com/article-1-5090-en.html
|
