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AWT IMAGE

AWT IMAGE

:: Volume 22, Issue 3 (7-2024) ::
Int J Radiat Res 2024, 22(3): 807-809 Back to browse issues page
Temozolomide Overdose in Treating High-Grade Glioma: A Case Report
A. Ebrahimi , D. Khoramian , N. Tabatabaei , S. Sarvizadeh
Department of Medical Physics, The Advocate Center for Clinical Research, Ayatollah Yasrebi Hospital, Kashan, Iran , daryoushkhoramian@gmail.com
Abstract:   (671 Views)
Here, we report a non-smoker, a 38-year-old male patient with High-Grade Glioma (HGG). The patient with the initial signs of swelling of his left arm and leg and dizziness without any nausea and vomiting and other neurological symptoms was referred to a neurosurgeon and then underwent Magnetic Resonance Imaging (MRI). The MRI showed the enhancement in T1 and T2 and flair. The radiologist suggested a tumor probably, HGG. The patient was treated with external beam radiation therapy (EBRT) with a total dose of 54 Gy in 27 fractions combined with the Temozolomide (TMZ) regime (75 mg/m2/day). The patient was prescribed 140 mg TMZ per day. By mistake, the patient received a 280 mg drug dose daily for 29 days. Due to this miscalculation, he was hospitalized and recovered for one month. After 30 months he is alive and is free of progression according to the MRI.
Keywords: Medication errors, Temozolomide, Chemotherapy Overdose, High-Grade Glioma.
Full-Text [PDF 729 kb]   (254 Downloads)    
Type of Study: Case Report | Subject: Radiation Biology
References
1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a Cancer Journal for Clinicians, 68(6): 394-424. [DOI:10.3322/caac.21492]
2. Hadziahmetovic M, Shirai K, Chakravarti A (2011) Recent advancements in multimodality treatment of gliomas. Future Oncology, 7(10): 1169-83. [DOI:10.2217/fon.11.102]
3. Ahmed R, Oborski MJ, Hwang M, Lieberman FS, Mountz JM (2014) Malignant gliomas: current perspectives in diagnosis, treatment, and early response assessment using advanced quantitative imaging methods. Cancer Management Research, 6: 149. [DOI:10.2147/CMAR.S54726]
4. Parvez K, Parvez A, Zadeh G (2014) The diagnosis and treatment of pseudoprogression, radiation necrosis and brain tumor recurrence. Int J Mol Sci, 15(7): 11832-46. [DOI:10.3390/ijms150711832]
5. Chowdhary MM, Ene CI, Silbergeld DL (2015) Treatment of Gliomas: How did we get here? Sur Neuro Int, 6(Suppl 1): S85. [DOI:10.4103/2152-7806.151348]
6. Raizer J, Parsa A. Current understanding and treatment of gliomas: Springer; 2015. [DOI:10.1007/978-3-319-12048-5]
7. Paolieri F, Sbrana A, Bloise F, Biasco E, Galli L (2018) Do We Need to Improve Oral Chemotherapy Adherence Monitoring? A Case Report of Temozolomide Overdose. Int J Case Rep, 2(1): 2.
8. Letarte N, Gabay MP, Bressler LR, Long KE, Stachnik JM, Villano JL (2014) Analyzing temozolomide medication errors: potentially fatal. Journal of Neuro-Oncology, 120(1): 111-5. [DOI:10.1007/s11060-014-1523-1]
9. Spence AM, Kiem H-P, Partap S, Schuetze S, Silber JR, Peterson RA (2006) Complications of a temozolomide overdose: a case report. Journal of Neuro-Oncology, 80: 57-61. [DOI:10.1007/s11060-006-9152-y]
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Ebrahimi A, Khoramian D, Tabatabaei N, Sarvizadeh S. Temozolomide Overdose in Treating High-Grade Glioma: A Case Report. Int J Radiat Res 2024; 22 (3) :807-809
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Volume 22, Issue 3 (7-2024) Back to browse issues page
International Journal of Radiation Research
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