[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
IJRR Information::
About the Journal
Editorial Board
Keywords
For Authors::
Aims and Scope
Call for Papers
Submission Instructions
For Reviewers::
Referee page
Subscription::
Subscription Form
News & Events::
Journal News
Web Mail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
ISSN
Hard Copy 2322-3243
Online 2345-4229
..
Online Submission
Now you can send your articles to IJRR office using the article submission system.
..

AWT IMAGE

AWT IMAGE
:: Volume 24, Issue 2 (4-2026) ::
Int J Radiat Res 2026, 24(2): 567-572 Back to browse issues page
Computerized tomography and magnetic resonance imaging features with quantitative T2 mapping of a primary malignant müllerian mixed tumor of the ovary: A case report
X. Wang , G. Sun , H. Zhang , M. Chen
Department of Ultrasound, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, China , chenminzhi_zhuhai@163.com
Abstract:   (350 Views)
Background: Ovarian Malignant Müllerian Mixed Tumor (MMMT), also named ovarian carcinosarcoma (OCS), is a rare and aggressive biphasic malignancy with malignant epithelial and mesenchymal components. Advanced magnetic resonance imaging (MRI) techniques like quantitative T2 mapping enable non-invasive tissue microstructural assessment, their diagnostic value for ovarian MMMT requires further elucidation with clinical case evidence. Case presentation: A 78-year-old female presented with chronic constipation and a pelvic mass. Imaging revealed a large, heterogeneous pelvic mass with peritoneal and omental involvement. Quantitative MRI analysis revealed a T2 mapping value of 148±18 ms and a low apparent diffusion coefficient (ADC) value of 0.98±0.08×10-3 mm2/s. Histopathological examination confirmed ovarian MMMT with heterologous chondrosarcoma components. Conclusion: This case demonstrates that quantitative MRI parameters, especially T2 mapping, can reflect the high-grade malignant microstructural features of ovarian MMMT. T2 mapping serves as a valuable non-invasive biomarker for characterizing this rare gynecological malignancy, potentially aiding in the differentiation of benign and malignant ovarian lesions and assessment of tumor aggressiveness.
Keywords: Ovarian malignant Müllerianmixed tumor, carcinosarcoma, magnetic resonance imaging, t2 mapping, apparent diffusion coefficient.
Full-Text [PDF 916 kb]   (139 Downloads)    
Type of Study: Case Report | Subject: Radiation Biology
References
1. 1. Xu, Q, Zhang X, Zou Y (2020) Primitive ovarian carcinosarcoma: a clinical and radiological analysis of five cases. J Ovarian Res, 13(1): 129. [DOI:10.1186/s13048-020-00728-2]
2. Gauci M and J Calleja-Agius (2024) Spotlight on carcinosarcoma of the ovary: A scoping review. Acta Medica (Hradec Kralove), 67(1): 1-11. [DOI:10.14712/18059694.2024.13]
3. Zhu L, Lu W, Wang F, Wang Y, Wu P-Y, Zhou J, Liu H (2023) Study of T2 mapping in quantifying and discriminating uterine lesions under different magnetic field strengths: 1.5 T vs. 3.0 T. BMC Med Imaging, 23(1): 1.
4. Ismail A, Choi S, Boussios S (2023) Frontiers of ovarian carcinosarcoma. Curr Treat Options Oncol, 24(12): 1667-1682. [DOI:10.1007/s11864-023-01138-4]
5. Jin X, Zhu P, Fan Sh, Dai J (2023) Magnetic resonance imaging for the diagnosis of malignant mixed Mullerian tumor of ovary: Two case reports. Medicine (Baltimore), 102(50): e36569. [DOI:10.1097/MD.0000000000036569]
6. Liu S, Peng M, Yu R, Jin C, Zhou Sh, Deng Y, Zhao D (2025) Predictive value of MR imaging IVIM and T2 mapping in malignant transformation of endometriosis. Medicine (Baltimore), 104(51): e46665. [DOI:10.1097/MD.0000000000046665]
7. Hollis RL, Croy I, Churchman M, Bartos C, Rye T, Gourley Ch, Herrington CS (2022) Ovarian carcinosarcoma is a distinct form of ovarian cancer with poorer survival compared to tubo-ovarian high-grade serous carcinoma. Br J Cancer, 127(6): 1034-1042. [DOI:10.1038/s41416-022-01874-8]
8. Belbaraka R, Taleb A, Errihani H (2010) A rare tumor of the ovary: Carcinosarcoma. Journal of Medical Cases, 1(2): 55-57. [DOI:10.4021/jmc1w]
9. Gagliardi T, Adejolu M, de Souza NM (2022) Diffusion-weighted magnetic resonance imaging in ovarian cancer: Exploiting strengths and understanding limitations. J Clin Med, 11(6): 1524. [DOI:10.3390/jcm11061524]
10. Zheng J, et al. (2023) Carcinosarcoma of the ovary: A case report and literature review. Front Oncol, 13: 1278300. [DOI:10.3389/fonc.2023.1278300]
11. Chu W and Huang D (2026) Pyroptosis-related gene signatures in ovarian cancer treatment follow-up using MRI. Int J Radiat Res, 24(1): 9-16. [DOI:10.66224/ijrr.24.1.2]
12. Liu R, et al. (2022) Apparent diffusion coefficient histogram analysis for differentiating solid ovarian tumors. Front Oncol, 12: 904323. [DOI:10.3389/fonc.2022.904323]
13. Lu X, Xie S, Mou D, Peng M (2025) Relationship between MRI imaging characteristics and serum markers CEA, CA199, CA125 levels in ovarian cancer patients. Int J Radiat Res, 23(3): p. 513-519. [DOI:10.61882/ijrr.23.3.1]
14. Matsuura Y, Kitajima M, Hachisuga T, Tanimoto A, Okura N, Kihara I (2010) Malignant mixed müllerian tumor with malignant neuroectodermal components (teratoid carcinosarcoma) of the ovary: Report of a case with clinicopathologic findings. J Obstet Gynaecol Res, 36(4): 907-11. [DOI:10.1111/j.1447-0756.2010.01238.x]
15. Sit AS, Price FV, Kelley JL, Comerci JT, Kunschner AJ, Kanbour-Shakir A, Edwards RP (2000) Chemotherapy for malignant mixed Müllerian tumors of the ovary. Gynecol Oncol, 79(2): 196-200. [DOI:10.1006/gyno.2000.5956]
16. Carter JS, Koopmeiners JS, Kuehn-Hajder JE, Metzger GJ, Lakkadi N, Downs Jr LS, Bolan PJ (2013) Quantitative multiparametric MRI of ovarian cancer. J Magn Reson Imaging, 38(6): 1501-9. [DOI:10.1002/jmri.24119]
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Wang X, Sun G, Zhang H, Chen M. Computerized tomography and magnetic resonance imaging features with quantitative T2 mapping of a primary malignant müllerian mixed tumor of the ovary: A case report. Int J Radiat Res 2026; 24 (2) :567-572
URL: http://ijrr.com/article-1-7080-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 24, Issue 2 (4-2026) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.14 seconds with 50 queries by YEKTAWEB 4741